The 1st house signifies your character, your personality, your perspective, temperament, health, beauty and your desires. The 6th house signifies health, colleagues, work space, responsibilities, diseases, enemies, conflicts, divorce, pets, small animals, and debts.
When your 1st lord is in the 6th house, it means your life path is closely connected with the matters of the 6th house. The result, of course, varies according to your Lagna lord. This house is generally known as an evil house. The reason is that it deals with the burdens.
Aries: Mars is your Lagna lord. It will be in the sign of Virgo. Mars is known as the soldier of the zodiac. When it comes to your 6th house of diseases, burdens, debts, and enemies, you will like to fight with these issues throughout your life. The failure and victory will be based on the planet sitting in that house, where the lord of 6th house sits, a condition of the 6th lord and aspects on it. You are capable of fighting with any adverse situations in life and full of confidence. You can even be a deal maker for those who are in trouble.
Taurus: Venus is your Lagna lord. It will be in Libra. Venus is love and care. This may mean that you are a caretaker. This is a difficult placement for Venus because the 6th house deals with harsh matters. Venus, being a very soft planet may not be always come out as the winner in adverse situations. The 6th house deals with lower class or people who live without any basic needs. When Venus, is in the 6th house, it means, you like to protect and motivate them. You may be having pets or you can even be a pet shop owner or veterinarian. You should have practical wisdom in handling relationships.
Gemini: Mercury is your Lagna lord. It will be in Scorpio. Mercury is an impatient planet and it revolves round Sun very fast. So he may make you explore the matters of the 6th house. You may own a pet shop or you may work with pets. You may be an accountant or someone working with finances as well. Because 6th house deals with debts and Scorpio deals with investments.
Cancer: Your Lagna lord is Moon. It will be in the sign of Sagittarius. The moon is mind, mother, emotions and delicate things in astrology. The 6th house deals with the harsh things, so the Moon may not be happy here. You may have to really pacify and strengthen your mind to deal with the issues in your life. You may have to fight for the peace in life. The good thing is that the Moon is sitting in the sign of Jupiter. This may give you strength to go through the issues. You may even become a deal maker in bringing peace into others life.
Leo: Sun is your Lagna lord. It will be in Capricorn. Sun is fire; it is the purest form of energy. It has the power to deal with the issues of the 6th house. Your enemies, diseases may not be a problem for you. You will have the strength to fight with all the issues in life. You will come out as a success in dealing with the adverse situation. This can even mean that you will be a deal maker for those who in trouble.
Virgo: Your 1st lord is Mercury. It will be in the sign of Aquarius. You may have similar situations like Gemini. You may have to adjust your thoughts to be peaceful. The 6th house deals with mental health also, so you may have to be careful with your enemies, debts, and colleagues.
Libra: Venus is your 1st lord. Venus will be in Pisces. In Pisces Venus is exalted. Exalted Venus should not throw in a pile of debt. Venus is a soft planet and you may feel distracted with your burdens. Pisces is the sign of spirituality; your life may force you to dependant in ultimate spirituality.
Scorpio: Mars is your Lagna lord. It will be in the sign of Aquarius. You can expect the same results as Aries. There can be enemies from your friend circles or business partners.
Sagittarius: Jupiter is your Lagna lord. It will be in the sign of Taurus. Jupiter is the teacher. This may mean that you are a deal maker. You may like to solve issues of people. Your main intention is to uplift people. You give solutions to people in troubles.
Capricorn: Saturn is your Lagna lord. It will be in the sign of Gemini. Saturn is a slow planet and an obstacle. This means you are finding easy to deal with your adverse situations. Saturn is a malefic planet and it will help you in dealing with debts, enemies, and adverse situations. This will help you in life.
Aquarius: Saturn is your Lagna lord. It will be in the sign of Cancer. You may expect same situations like Capricorn. The relationship with the mother can be a problem.
Pisces: Jupiter is your Lagna lord. It will be in the sign of Leo. You may expect same situations like Sagittarius. You may be busy in teaching ancient texts.